Peptide Database

Delta Sleep Inducing Peptide · Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu

DSIP (Delta Sleep Inducing Peptide) is a nonapeptide first isolated from rabbit cerebral venous blood during electrically induced sleep. Research shows it promotes slow-wave sleep, reduces pain sensitivity, normalizes circadian rhythms, lowers cortisol, and exhibits stress-protective effects. It also stimulates LH release and may influence GH pulsatility. Multiple mechanisms of action are proposed; its receptor has not been fully characterized.

NPY

Neuropeptide Y (NPY) is a 36-amino-acid peptide and the most abundant neuropeptide in the mammalian CNS, acting through Y1–Y6 receptors. It is a potent orexigenic signal (stimulating appetite and fat storage), anxiolytic agent, vasoconstrictor, and regulator of circadian rhythms. Paradoxically, peripheral NPY promotes fat accumulation while central NPY drives food intake — making it a complex but high-priority metabolic research target.