Peptide Database

MGF · IGF-1Ec

Mechano Growth Factor (MGF) is a splice variant of the IGF-1 gene expressed in response to mechanical loading and muscle damage. Unlike systemic IGF-1, MGF activates satellite cells (muscle stem cells) to proliferate before differentiating — a critical step in muscle repair and growth. Research indicates it plays a distinct, non-overlapping role with systemic IGF-1 in tissue regeneration.

PEGylated Mechano Growth Factor

PEG-MGF is a PEGylated (polyethylene glycol-modified) form of Mechano Growth Factor, designed to dramatically extend its biological half-life from minutes to days while preserving activity. PEGylation allows systemic delivery and sustained satellite cell activation without the need for local injection. Research shows enhanced muscle hypertrophy signaling compared to unmodified MGF.