Peptide Database

Matrixyl · Pal-KTTKS

Palmitoyl Pentapeptide-4 (Matrixyl) is a lipopeptide widely used in cosmetic anti-aging formulations. It is derived from the procollagen type I sequence and acts as a matrikine, signaling skin cells to produce collagen, elastin, fibronectin, and hyaluronic acid. Clinical studies demonstrate measurable reduction in wrinkle depth and improved skin elasticity with topical application.

Pal-GHK · Matrixyl component

Palmitoyl Tripeptide-1 is a lipopeptide created by palmitoylating GHK (glycyl-histidyl-lysine), the same sequence as GHK-Cu without copper. The palmitoyl group enhances skin penetration, while the GHK sequence signals fibroblasts to upregulate collagen, elastin, and hyaluronic acid synthesis. It is a primary active ingredient in Matrixyl formulations and widely used in anti-aging cosmetics with clinical data supporting wrinkle reduction.