Overview
Palmitoyl Tripeptide-1 is a lipopeptide created by palmitoylating GHK (glycyl-histidyl-lysine), the same sequence as GHK-Cu without copper. The palmitoyl group enhances skin penetration, while the GHK sequence signals fibroblasts to upregulate collagen, elastin, and hyaluronic acid synthesis. It is a primary active ingredient in Matrixyl formulations and widely used in anti-aging cosmetics with clinical data supporting wrinkle reduction.
Routes of Administration
Anti-aging cosmetic creams and serums
Research Profile
Mechanism of Action
Pharmacokinetics
Key Research Findings
Side Effects & Safety
Research Search Terms
Links open PubMed searches for peer-reviewed studies on this peptide.
Frequently Asked Questions
Palmitoyl Tripeptide-1 is a lipopeptide created by palmitoylating GHK (glycyl-histidyl-lysine), the same sequence as GHK-Cu without copper. The palmitoyl group enhances skin penetration, while the GHK sequence signals fibroblasts to upregulate collagen, elastin, and hyaluronic acid synthesis. It is a primary active ingredient in Matrixyl formulations and widely used in anti-aging cosmetics with clinical data supporting wrinkle reduction.
The reported half-life of Palmitoyl Tripeptide-1 is Topical; designed for dermal penetration. Half-life refers to the time required for the plasma concentration to decrease by half through metabolic clearance.
In research settings, Palmitoyl Tripeptide-1 is typically administered via: topical. Route selection affects onset, bioavailability, and duration of action.
Palmitoyl Tripeptide-1 is currently at the Preclinical research — studied in cell cultures and animal models, with no approved human clinical trials. stage.
Palmitoyl Tripeptide-1 profiles on Peptide United are for research and educational purposes only. This compound is not approved for human therapeutic use unless specifically noted. Always consult a qualified healthcare professional.
Related Compounds