Peptide Database

Beta-Alanyl-N-methyl-L-histidine

Anserine is a methylated dipeptide analog of carnosine found in high concentrations in avian and fish muscle. It shares carnosine's pH-buffering and antioxidant properties but shows superior blood-brain barrier penetration. Research highlights potential for cognitive decline prevention, reduction of amyloid-beta toxicity, and improved exercise performance. It is often studied alongside carnosine for synergistic effects.

CJC-1295 with DAC · DAC:GRF

CJC-1295 is a modified GHRH analog with a Drug Affinity Complex (DAC) that binds to serum albumin, dramatically extending its half-life compared to native GHRH. It produces sustained elevation of GH and IGF-1 levels over days rather than hours. Research focuses on body composition improvements, muscle growth, and fat loss through prolonged GH axis stimulation.

C₁₅₂H₂₅₂N₄₂O₄₂S · 3647.28 Da

Growth Hormone-Releasing Hormone · Somatoliberin

GHRH is the endogenous 44-amino-acid hypothalamic peptide that drives the pulsatile secretion of growth hormone from the anterior pituitary. Native GHRH acts through GHRHR, stimulating GH gene transcription and secretion. It has a very short half-life in vivo, making it impractical as a therapeutic — which drove the development of modified analogs like sermorelin, CJC-1295, and tesamorelin. Research into GHRH receptor signaling underpins the entire GH secretagogue drug class.

Glucagon-like Peptide-1 · GLP-1(7-37)

GLP-1 is an endogenous incretin hormone secreted by intestinal L-cells in response to nutrient ingestion. It enhances glucose-dependent insulin secretion, suppresses glucagon, slows gastric emptying, and signals satiety to the hypothalamus. Native GLP-1 has a half-life of only 1–2 minutes due to DPP-4 degradation, which drove the development of DPP-4-resistant analogs (semaglutide, liraglutide, exenatide) that are now major drug classes.

Pentapeptide-18

Leuphasyl is a pentapeptide that acts as an enkephalin analog, binding to δ-opioid receptors on muscle cells and neuronal cells to modulate acetylcholine release and reduce muscle contraction. Often combined with Argireline in cosmetic formulations for a synergistic anti-wrinkle effect, studies show the combination outperforms either compound alone in reducing crow's feet and forehead lines.

MT-II · MT2

Melanotan II is a cyclic synthetic analog of α-MSH that non-selectively activates melanocortin receptors (MC1R–MC5R). It induces skin tanning (via MC1R), erectile function (via MC4R), and sexual arousal while also suppressing appetite. It was the precursor compound from which PT-141 was developed. Research continues despite regulatory concerns due to its broad receptor activity profile.

NT · NTS

Neurotensin is a 13-amino-acid neuropeptide found in the brain and GI tract. Centrally, it modulates dopamine circuits, acts as an endogenous antipsychotic-like agent, and is analgesic. Peripherally, it inhibits gastric acid secretion, stimulates pancreatic secretion, and promotes fat absorption. Research explores neurotensin analogs for pain, schizophrenia, Parkinson's disease, and metabolic regulation.

Alpha-Melanocyte-Stimulating Hormone · α-Melanotropin

α-MSH is an endogenous 13-amino-acid peptide derived from POMC (pro-opiomelanocortin). It activates MC1R to stimulate melanin production in skin, MC4R to suppress appetite and regulate energy expenditure, and MC3R/MC1R to exert potent anti-inflammatory effects. It is the parent compound from which many synthetic melanocortin analogs (Melanotan I, II, PT-141, KPV) were derived and remains a cornerstone of melanocortin pharmacology research.