Peptide Database

Thymalfasin · Tα1

Thymosin Alpha-1 is a naturally occurring 28-amino-acid peptide derived from thymosin fraction 5 of the thymus gland. Approved in over 35 countries for hepatitis B, hepatitis C, and as an immune adjuvant in cancer therapy, it enhances T-cell maturation, dendritic cell function, and NK cell activity. Research continues to expand into sepsis, COVID-19, autoimmune conditions, and vaccine response enhancement.

C₁₂₉H₂₁₅N₃₃O₅₅ · 3108.29 Da

Mounjaro · Zepbound

Tirzepatide is the first dual GIP/GLP-1 receptor agonist, approved for type 2 diabetes (Mounjaro) and obesity (Zepbound). By co-activating both incretin receptors, it achieves superior glycemic control and weight reduction compared to GLP-1 monotherapy — SURMOUNT trials showed up to 22.5% body weight reduction. It represents a new class of metabolic peptide therapeutics with broad cardiovascular and metabolic benefits.

Thyrotropin-Releasing Hormone · Thyroliberin

TRH is a tripeptide (pGlu-His-Pro-NH2) produced in the hypothalamus that stimulates TSH and prolactin release from the anterior pituitary. Beyond thyroid regulation, TRH has direct CNS effects — it is alerting, antidepressant, neuroprotective, and anticonvulsant. Research explores TRH analogs (taltirelin, approved in Japan) for ALS, spinal cord injury, Alzheimer's disease, and treatment-resistant depression, avoiding thyroid side effects.

ADH · Antidiuretic Hormone

Vasopressin (AVP) is a 9-amino-acid neuropeptide produced in the hypothalamus and released by the posterior pituitary. It regulates water reabsorption via V2 receptors in renal collecting ducts and vasoconstriction via V1a receptors in blood vessels. Clinically used for diabetes insipidus, septic shock vasodilation, GI hemorrhage, and cardiac arrest. Extensive research also examines its roles in social bonding, memory, and stress responses.