Peptide Database

MEHFPGP · Pro8-Gly9-Pro10-ACTH(4–10)

Semax is a synthetic heptapeptide analog of ACTH(4-7) developed in Russia, where it is approved for stroke, TBI, peptic ulcers, and cognitive enhancement. It upregulates BDNF and its receptor TrkB, promotes dopamine and serotonin turnover, and has demonstrated neuroprotective effects in ischemia models. Research highlights improvements in attention, memory, and recovery from neurological injury.

Thyrotropin-Releasing Hormone · Thyroliberin

TRH is a tripeptide (pGlu-His-Pro-NH2) produced in the hypothalamus that stimulates TSH and prolactin release from the anterior pituitary. Beyond thyroid regulation, TRH has direct CNS effects — it is alerting, antidepressant, neuroprotective, and anticonvulsant. Research explores TRH analogs (taltirelin, approved in Japan) for ALS, spinal cord injury, Alzheimer's disease, and treatment-resistant depression, avoiding thyroid side effects.