Peptide Database

Beta-Alanyl-N-methyl-L-histidine

Anserine is a methylated dipeptide analog of carnosine found in high concentrations in avian and fish muscle. It shares carnosine's pH-buffering and antioxidant properties but shows superior blood-brain barrier penetration. Research highlights potential for cognitive decline prevention, reduction of amyloid-beta toxicity, and improved exercise performance. It is often studied alongside carnosine for synergistic effects.

MEHFPGP · Pro8-Gly9-Pro10-ACTH(4–10)

Semax is a synthetic heptapeptide analog of ACTH(4-7) developed in Russia, where it is approved for stroke, TBI, peptic ulcers, and cognitive enhancement. It upregulates BDNF and its receptor TrkB, promotes dopamine and serotonin turnover, and has demonstrated neuroprotective effects in ischemia models. Research highlights improvements in attention, memory, and recovery from neurological injury.

Thyrotropin-Releasing Hormone · Thyroliberin

TRH is a tripeptide (pGlu-His-Pro-NH2) produced in the hypothalamus that stimulates TSH and prolactin release from the anterior pituitary. Beyond thyroid regulation, TRH has direct CNS effects — it is alerting, antidepressant, neuroprotective, and anticonvulsant. Research explores TRH analogs (taltirelin, approved in Japan) for ALS, spinal cord injury, Alzheimer's disease, and treatment-resistant depression, avoiding thyroid side effects.