Peptide Database

AM

Adrenomedullin is a 52-amino-acid vasoactive peptide originally isolated from human pheochromocytoma. It is a potent vasodilator acting through CGRP receptors, promotes natriuresis, reduces inflammation, protects vascular endothelial barrier function, and enhances wound healing. Circulating AM levels rise in heart failure, sepsis, and critical illness — making it both a biomarker and emerging therapeutic target.

Trappin-2 · SKALP

Elafin is an endogenous serine protease inhibitor (serpin-like) peptide produced by epithelial cells at mucosal surfaces. It inhibits neutrophil elastase and proteinase 3, protecting tissues from excessive inflammatory damage, while also exhibiting direct antimicrobial activity against bacteria and fungi. Research focuses on inflammatory bowel disease, cystic fibrosis, ARDS, and vaginal microbiome modulation, where recombinant elafin is in Phase 2 trials.

Tβ4 · LKKTETQ

Thymosin Beta-4 is the full-length 43-amino-acid peptide and one of the most abundant intracellular proteins in mammalian cells. It sequesters G-actin, regulating actin polymerization and cell motility, which underpins its role in wound healing, cardiac repair, and immune cell migration. Clinical trials have examined it for dry eye disease, epidermolysis bullosa, and cardiac repair after myocardial infarction.