Peptide Database

Trappin-2 · SKALP

Elafin is an endogenous serine protease inhibitor (serpin-like) peptide produced by epithelial cells at mucosal surfaces. It inhibits neutrophil elastase and proteinase 3, protecting tissues from excessive inflammatory damage, while also exhibiting direct antimicrobial activity against bacteria and fungi. Research focuses on inflammatory bowel disease, cystic fibrosis, ARDS, and vaginal microbiome modulation, where recombinant elafin is in Phase 2 trials.

Serelaxin · H2 relaxin

Relaxin-2 is an endogenous peptide hormone structurally related to insulin, primarily known for its role in pregnancy (cervical ripening, joint laxity). Research discovered its potent anti-fibrotic properties — it remodels collagen networks in heart, kidney, lung, and liver — making it a leading candidate for fibrosis and acute heart failure. Serelaxin (recombinant relaxin) reached Phase 3 trials for acute heart failure with promising early signals but did not meet primary endpoints.