Peptide Database

CJC-1295 with DAC · DAC:GRF

CJC-1295 is a modified GHRH analog with a Drug Affinity Complex (DAC) that binds to serum albumin, dramatically extending its half-life compared to native GHRH. It produces sustained elevation of GH and IGF-1 levels over days rather than hours. Research focuses on body composition improvements, muscle growth, and fat loss through prolonged GH axis stimulation.

C₁₅₂H₂₅₂N₄₂O₄₂S · 3647.28 Da

Long R3 IGF-1 · Insulin-like Growth Factor 1 Long R3

IGF-1 LR3 is a modified version of Insulin-like Growth Factor-1 with an arginine substitution and 13-amino-acid N-terminal extension, which reduces binding to IGF-binding proteins and extends its half-life. It promotes muscle cell hyperplasia and hypertrophy by activating the PI3K/AKT/mTOR pathway. Research explores its role in muscle wasting, recovery from injury, and anabolic signaling.

Insulin-like Growth Factor 2 · Somatomedin A

IGF-2 is a 67-amino-acid peptide growth factor closely related to IGF-1, primarily active during fetal and neonatal development. In adults, research highlights its potent cognitive effects — IGF-2 administration after training enhances long-term memory consolidation in rodents by a remarkable degree, acting through IGF2R and mannose-6-phosphate receptors in the hippocampus. It has also emerged as a candidate for treating cognitive deficits in aging and neurodegenerative disease.

MGF · IGF-1Ec

Mechano Growth Factor (MGF) is a splice variant of the IGF-1 gene expressed in response to mechanical loading and muscle damage. Unlike systemic IGF-1, MGF activates satellite cells (muscle stem cells) to proliferate before differentiating — a critical step in muscle repair and growth. Research indicates it plays a distinct, non-overlapping role with systemic IGF-1 in tissue regeneration.