Peptide Database

FGF-21

FGF-21 is a 181-amino-acid endocrine fibroblast growth factor secreted by the liver under fasting conditions. It promotes fatty acid oxidation, ketogenesis, insulin sensitization, and thermogenesis in brown adipose tissue. Animal studies show it extends lifespan and reverses metabolic syndrome. Long-acting FGF-21 analogs and fusion proteins (efruxifermin, pegbelfermin) are in Phase 2–3 trials for NASH, type 2 diabetes, and dyslipidemia.

PYY · PYY3-36

Peptide YY (PYY) is a 36-amino-acid gut hormone released by L-cells postprandially. The truncated form PYY3-36 is the predominant circulating form and acts as a potent satiety signal by inhibiting NPY neurons in the hypothalamic arcuate nucleus. Research and early clinical trials demonstrate that PYY3-36 administration significantly reduces food intake. It represents a key component of gut-brain appetite regulation studied for obesity treatment.