Peptide Database

LY3437943

Retatrutide is a triple agonist targeting GIP, GLP-1, and glucagon receptors simultaneously. Phase 2 trials demonstrated up to 24.2% body weight reduction — the highest achieved by any pharmacotherapy to date. The addition of glucagon agonism enhances energy expenditure and lipid metabolism beyond dual incretin agonists. Phase 3 trials are underway for obesity and NASH.