Peptide Database

Davunetide · NAPVSIPQ

NAP (NAPVSIPQ) is an 8-amino-acid neuroprotective peptide derived from activity-dependent neuroprotective protein (ADNP). It stabilizes microtubules by interacting with tubulin, protecting neurons against tau pathology, amyloid toxicity, and oxidative damage. Phase 2 trials in schizophrenia and progressive supranuclear palsy have been completed; research is ongoing for Alzheimer's disease and autism spectrum disorder.

UCN1 · Urocortin

Urocortin 1 (UCN1) is a 40-amino-acid member of the CRH peptide family that activates both CRHR1 and CRHR2 receptors. It has potent cardioprotective effects — improving cardiac contractility, reducing ischemia-reperfusion injury, and stimulating natriuresis — making it a significant heart failure research target. It also modulates anxiety and appetite centrally. Phase 2 trials for chronic heart failure showed improvements in cardiac function.