Peptide Database

AM

Adrenomedullin is a 52-amino-acid vasoactive peptide originally isolated from human pheochromocytoma. It is a potent vasodilator acting through CGRP receptors, promotes natriuresis, reduces inflammation, protects vascular endothelial barrier function, and enhances wound healing. Circulating AM levels rise in heart failure, sepsis, and critical illness — making it both a biomarker and emerging therapeutic target.

Ang(1-7) · A779 counter-regulatory

Angiotensin 1-7 is a 7-amino-acid peptide of the renin-angiotensin system (RAS) and the primary product of ACE2 enzyme activity. It opposes the vasoconstrictive, pro-inflammatory actions of Angiotensin II by acting on the Mas receptor — promoting vasodilation, natriuresis, anti-fibrosis, and anti-inflammation. Extensively studied for heart failure, hypertension, and COVID-19, it represents the counter-regulatory arm of the RAS.

Examorelin · EP 23905

Hexarelin is one of the most potent synthetic GHRP compounds, producing the largest GH pulse among GHRPs. Beyond its GH-stimulating properties, research highlights direct cardioprotective effects through CD36 receptor binding, independent of GH or IGF-1. Studies show benefits in heart failure models, myocardial infarction recovery, and protection against ventricular dysfunction.

Elamipretide · Szeto-Schiller 31

SS-31 (elamipretide) is a tetrapeptide that selectively targets cardiolipin in the inner mitochondrial membrane, stabilizing cristae architecture and enhancing ATP synthesis efficiency. It reduces mitochondrial ROS production and protects against ischemia-reperfusion injury, heart failure, and aging-related mitochondrial dysfunction. Phase 2 trials have been conducted for heart failure with preserved ejection fraction and Barth syndrome.

Tβ4 · LKKTETQ

Thymosin Beta-4 is the full-length 43-amino-acid peptide and one of the most abundant intracellular proteins in mammalian cells. It sequesters G-actin, regulating actin polymerization and cell motility, which underpins its role in wound healing, cardiac repair, and immune cell migration. Clinical trials have examined it for dry eye disease, epidermolysis bullosa, and cardiac repair after myocardial infarction.

UCN1 · Urocortin

Urocortin 1 (UCN1) is a 40-amino-acid member of the CRH peptide family that activates both CRHR1 and CRHR2 receptors. It has potent cardioprotective effects — improving cardiac contractility, reducing ischemia-reperfusion injury, and stimulating natriuresis — making it a significant heart failure research target. It also modulates anxiety and appetite centrally. Phase 2 trials for chronic heart failure showed improvements in cardiac function.

Vasoactive Intestinal Peptide · Vasoactive Intestinal Polypeptide

VIP (Vasoactive Intestinal Peptide) is a 28-amino-acid neuropeptide with pleiotropic anti-inflammatory, bronchodilatory, and immunomodulatory effects mediated through VPAC1 and VPAC2 receptors. Research spans pulmonary arterial hypertension (inhaled VIP trials), inflammatory bowel disease, sepsis, Parkinson's disease, and CIRS (chronic inflammatory response syndrome). It suppresses Th1 cytokines and promotes Treg cell function.