Peptide Database

Elamipretide · Szeto-Schiller 31

SS-31 (elamipretide) is a tetrapeptide that selectively targets cardiolipin in the inner mitochondrial membrane, stabilizing cristae architecture and enhancing ATP synthesis efficiency. It reduces mitochondrial ROS production and protects against ischemia-reperfusion injury, heart failure, and aging-related mitochondrial dysfunction. Phase 2 trials have been conducted for heart failure with preserved ejection fraction and Barth syndrome.