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102 evidence-graded profiles. Every mechanism traced to primary literature. Free to read.

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16categories
1,200+citations
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Retatrutide

Phase III

LY3437943

Retatrutide is a triple agonist targeting GIP, GLP-1, and glucagon receptors simultaneously. Phase 2 trials demonstrated up to 24.2% body weight reduction — the highest achieved by any pharmacotherapy to date. The addition of glucagon agonism enhances energy expenditure and lipid metabolism beyond dual incretin agonists. Phase 3 trials are underway for obesity and NASH.

Formula
Weight
GLP-1 & Metabolic HormonesFat Loss & Metabolic

Semaglutide

Approved

Ozempic · Wegovy

Semaglutide is a long-acting GLP-1 receptor agonist approved for type 2 diabetes (Ozempic, Rybelsus) and obesity (Wegovy). By mimicking the incretin hormone GLP-1, it enhances glucose-dependent insulin secretion, suppresses glucagon, slows gastric emptying, and reduces appetite via central hypothalamic pathways. Landmark trials demonstrate up to 15–17% body weight reduction and significant cardiovascular mortality benefit.

Formula
Weight
GLP-1 & Metabolic HormonesFat Loss & MetabolicCardiovascular

Tesamorelin

Approved

Egrifta · TH9507

Tesamorelin is a stabilized synthetic GHRH analog FDA-approved for reduction of excess abdominal fat in HIV-infected adults with lipodystrophy. It stimulates pulsatile GH secretion while preserving natural feedback regulation. Research demonstrates significant visceral adipose tissue reduction, improved lipid profiles, and cognitive benefits, making it a key study compound for metabolic dysfunction.

Formula
Weight
Growth Hormone AxisFat Loss & Metabolic

Ipamorelin

Preclinical

NNC 26-0161

Ipamorelin is a selective growth hormone secretagogue and ghrelin receptor agonist. Unlike other GHRPs, it stimulates GH release with high selectivity — producing minimal cortisol, ACTH, or prolactin elevation. It is among the most studied GHRPs for its clean GH pulse profile, making it a preferred research peptide for GH axis studies with reduced side effect concern.

FormulaC₃₈H₄₉N₉O₅
Weight711.86 Da
Growth Hormone Axis

CJC-1295

Preclinical

CJC-1295 with DAC · DAC:GRF

CJC-1295 is a modified GHRH analog with a Drug Affinity Complex (DAC) that binds to serum albumin, dramatically extending its half-life compared to native GHRH. It produces sustained elevation of GH and IGF-1 levels over days rather than hours. Research focuses on body composition improvements, muscle growth, and fat loss through prolonged GH axis stimulation.

FormulaC₁₅₂H₂₅₂N₄₂O₄₂S
Weight3647.28 Da
Growth Hormone Axis

GHK-Cu

Preclinical

Copper Peptide GHK · Glycyl-L-histidyl-L-lysine copper

GHK-Cu is a naturally occurring copper-binding tripeptide found in human plasma, saliva, and urine. Research demonstrates it stimulates collagen, elastin, and glycosaminoglycan synthesis, promotes wound healing, reduces inflammation, and activates protective antioxidant genes. Plasma levels decline with age, making it a significant anti-aging research target.

FormulaC₁₄H₂₄CuN₆O₄
Weight340.84 Da (free ligand)
Healing & RecoverySkin & CosmeticAnti-Aging & Longevity

TB-500

Preclinical

Thymosin Beta-4 Fragment · Tβ4 fragment

TB-500 is a synthetic version of the active region of Thymosin Beta-4, a naturally occurring peptide found in virtually all human cells. Research shows it promotes actin polymerization and cell migration, which accelerates wound healing, muscle repair, and vascular growth. It is particularly studied for its ability to reduce inflammation and promote cardiac tissue repair.

FormulaC₂₁₂H₃₅₀N₅₆O₇₈S
Weight4963.44 Da
Healing & RecoveryMuscle & PerformanceCardiovascular

BPC-157

Preclinical

Body Protection Compound 157 · PL 14736

BPC-157 is a 15-amino-acid peptide fragment derived from human gastric juice. It is one of the most extensively researched peptides for tissue repair, demonstrating accelerated healing of tendons, ligaments, muscle, bone, and gut lining in animal models. It appears to upregulate growth hormone receptors and promote angiogenesis at injury sites.

FormulaC₆₂H₉₈N₁₆O₂₂
Weight1419.55 Da
Healing & RecoveryPain & InflammationCognitive Enhancement

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Research profile

Preclinical

BPC-157

Free

A 15-amino acid partial sequence of Body Protection Compound, derived from human gastric juice. Studied extensively in rodent models for tissue repair, tendon healing, and gastrointestinal protection.

Mechanism of action

BPC-157 upregulates vascular endothelial growth factor (VEGF) and its receptor VEGFR2, promoting angiogenesis at injury sites. It also sensitizes growth hormone receptors on tendon fibroblasts via the FAK-paxillin pathway, and modulates nitric oxide synthesis through…

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